• Users Online: 107
  • Home
  • Print this page
  • Email this page
Home About us ASMR Conference Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2012  |  Volume : 7  |  Issue : 2  |  Page : 86-91

Study of the pituitary– gonadal axis in the proestrus phase in adult female rats subjected to social isolation


Department of Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Nehal M. Bahgat
Department of Physiology, Faculty of Medicine, Ain Shams University, 11733 Cairo
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Background/aim Social isolation is a type of stress that might adversely affect sex cycles in both animals and humans. The present study was planned to investigate the pituitary-gonadal axis in the proestrus phase of estrous cycle in adult female rats subjected to social isolation stress for 8 weeks. Materials and methods Twenty Sprague-Dawley adult female rats were divided into two experimental groups: a control group (n = 10) and a socially isolated group (SI, n = 10). Throughout the study, all rats were monitored for body weight and food intake. After 8 weeks, rats were sacrificed in the proestrus phase of estrous cycle. All rats were examined for final body weight, rectal temperature, hematocrit value, and serum levels of follicle stimulating hormone, luteinizing hormones, prolactin hormone, 17-b estradiol, and progesterone in addition to histological examination of the ovaries. Results The results of the present study showed that the SI group had significant decrease in their final body weights and their serum levels of 17-b estradiol and progesterone, whereas the serum level of prolactin was significantly increased. Histological examination of SI rat ovaries showed fewer growing ovarian follicles and numerous atretic ones compared to control rat ovaries. Conclusion These findings indicate that social isolation might result in depressed ovarian function in adult female rats.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed425    
    Printed30    
    Emailed0    
    PDF Downloaded53    
    Comments [Add]    

Recommend this journal