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ORIGINAL ARTICLE
Year : 2012  |  Volume : 7  |  Issue : 2  |  Page : 92-96

Amelioratory effects of vitamin E against biochemical toxicity induced by deltamethrin in male rats


Department of Applied Organic Chemistry, National Research Centre, Dokki, Giza, Egypt

Correspondence Address:
Somia El Maghraby
Department of Applied Organic Chemistry, National Research Centre, Dokki, Giza
Egypt
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Source of Support: None, Conflict of Interest: None


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Background/aim Deltamethrin (DLM) is a synthetic pyrethroid insecticide known for its wide toxic manifestations. The present experiment pertains to the protective role of vitamin E (vit E) against biochemical toxicity following pesticide exposure during 30 days. Materials and methods Male albino rats were divided into four groups of six each: Group I served as control rats (0 mg (vit E) and 0 mg DLM/kg body weight), Group II received deltamethrin (7.5mg/kg body weight). Group III received vit E (100 mg/kg body weight). Group IV received both deltamethrin (7.5mg/kg body weight) plus vit E (100mg/kg body weight). Results Exposure of rats to DLM induced significant increase in the levels of hepatic markers enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP); while acetylcholinesterase (AChE) was inhibited. Significant decrease in catalase (CAT) and glutathione S-transferase (GST) enzyme activities were observed in treated rats. Furthermore, renal markers such as urea and creatinine were increased in deltamethrin treated rats. Additionally, serum cholesterol, triglycerides, low-density lipoprotein (LDL) and the level of high-density lipoprotein (HDL) were significantly increased and decreased, respectively. Co-administration of vit E restored all the parameters cited above to near-normal values. Conclusion Our investigation showed that vit E acts as an effective antioxidant for DLM pesticide toxicity in reducing oxidative stress burden.


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