| ORIGINAL ARTICLE |
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| Year : 2017 | Volume
: 12
| Issue : 2 | Page : 39-45 |
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Cardioprotective effects of vitamin B complex and Ethinyl Estradiol in ovariectomized rats
Bassant M.M Ibrahim1, Hanan F Al-Saeed2, Aziza B Shalby3
1 Department of Pharmacology, National Research Centre, Giza, Egypt
2 Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
3 Department of Hormones, National Research Centre, Giza, Egypt
Correspondence Address:
Bassant M.M Ibrahim
Department of Pharmacology, National Research Centre, El-Bohouth Street (former El-Tahrir Street), Dokki, PO Box 12622, Giza
Egypt
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jasmr.jasmr_6_17
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Background/aim Reduction of female sex hormones is associated with health disorders including cardiovascular diseases such as hypertension. Supplementation with vitamin B complex can lower the incidence of these disorders. The present study aimed to study the potential cardioprotective effects of vitamin B complex and ethinyl estradiol (EE) when administered alone or in combination to hormonal-deprived ovariectomized (OVX) rats.
Materials and methods Fifty female Wister rats were classified into five equal groups: the first group included normal rats, the second group was OVX (positive control), and the third to fifth groups were OVX rats that were treated by EE (0.03 mg/kg), vitamin B complex (9.036 mg/kg), and a combination of both treatments, respectively. Treatment continued for eight successive weeks. Blood pressure (BP), cystathionine γ-lyase (CSE), reduced glutathione (R-GSH), superoxide dismutase (SOD), catalase (CAT), and interleukin-β6 (IL-β6) were measured.
Results The OVX rats showed a significant increase in BP, reduction in CSE, R-GSH, SOD, and CAT, and increase in IL-β6 levels, whereas the treated OVX rats showed a significant decrease in BP, increase in CSE, R-GSH, SOD, and CAT, and reduction in IL-β6 levels.
Conclusion Vitamin B complex and EE exert cardioprotective effects in OVX rats.
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