• Users Online: 193
  • Home
  • Print this page
  • Email this page
Home About us ASMR Conference Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2017  |  Volume : 12  |  Issue : 2  |  Page : 39-45

Cardioprotective effects of vitamin B complex and Ethinyl Estradiol in ovariectomized rats


1 Department of Pharmacology, National Research Centre, Giza, Egypt
2 Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
3 Department of Hormones, National Research Centre, Giza, Egypt

Correspondence Address:
Bassant M.M Ibrahim
Department of Pharmacology, National Research Centre, El-Bohouth Street (former El-Tahrir Street), Dokki, PO Box 12622, Giza
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jasmr.jasmr_6_17

Rights and Permissions

Background/aim Reduction of female sex hormones is associated with health disorders including cardiovascular diseases such as hypertension. Supplementation with vitamin B complex can lower the incidence of these disorders. The present study aimed to study the potential cardioprotective effects of vitamin B complex and ethinyl estradiol (EE) when administered alone or in combination to hormonal-deprived ovariectomized (OVX) rats. Materials and methods Fifty female Wister rats were classified into five equal groups: the first group included normal rats, the second group was OVX (positive control), and the third to fifth groups were OVX rats that were treated by EE (0.03 mg/kg), vitamin B complex (9.036 mg/kg), and a combination of both treatments, respectively. Treatment continued for eight successive weeks. Blood pressure (BP), cystathionine γ-lyase (CSE), reduced glutathione (R-GSH), superoxide dismutase (SOD), catalase (CAT), and interleukin-β6 (IL-β6) were measured. Results The OVX rats showed a significant increase in BP, reduction in CSE, R-GSH, SOD, and CAT, and increase in IL-β6 levels, whereas the treated OVX rats showed a significant decrease in BP, increase in CSE, R-GSH, SOD, and CAT, and reduction in IL-β6 levels. Conclusion Vitamin B complex and EE exert cardioprotective effects in OVX rats.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed739    
    Printed117    
    Emailed0    
    PDF Downloaded138    
    Comments [Add]    

Recommend this journal