Journal of The Arab Society for Medical Research

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 9  |  Issue : 1  |  Page : 28--32

The association between serum thyroid-stimulating hormone concentration and development of differentiated thyroid cancers in nodular thyroid disease


Mohammad Arafat, Sameh Gabr, Ibrahim A Ghaffar, Ahmad A Rahman, Zakaria Hamza, Ahmad A Fattah, Mohammad A Fattah, Mohammad Mira 
 Department of General Surgery, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Correspondence Address:
Ibrahim A Ghaffar
Department of General Surgery, Faculty of Medicine, Al-Azhar University, Cairo
Egypt

Objective To evaluate the relation between serum thyroid-stimulating hormone (TSH) and development of differentiated thyroid cancers in nodular thyroid disease (NTD) in Egyptians. Patients and methods One hundred patients were included in this study at Al-Azhar University Hospitals from 2010 to 2013; all patients with NTD, who were fit for surgery, were selected for study. The preoperative TSH level was estimated and was compared with the final histopathological diagnosis for the presence of malignant thyroid lesions. Results A total of 100 patients were included in the study, with an average age of 46 years. The male to female ratio was 1 : 4.7. Seventy-five patients had multinodular goiter, whereas 25 patients had a solitary thyroid nodule. Eighty-six patients underwent total thyroidectomy, whereas 14 patients underwent near- total thyroidectomy. The final histopathological data showed no evidence of malignancy in 83 patients, 83% (benign group), whereas malignant lesions were present in 17 patients, 17% (malignant group). The preoperative mean TSH level in the benign group was 1.72 ± 1.4 mIU/L, whereas the mean TSH concentration in the malignant group was 2.61 ± 2.2 mIU/l. Conclusion There is a definite relation between serum TSH and development of differentiated thyroid cancers in NTD as the risk of thyroid malignancy increases with increased serum TSH concentrations.


How to cite this article:
Arafat M, Gabr S, Ghaffar IA, Rahman AA, Hamza Z, Fattah AA, Fattah MA, Mira M. The association between serum thyroid-stimulating hormone concentration and development of differentiated thyroid cancers in nodular thyroid disease.J Arab Soc Med Res 2014;9:28-32


How to cite this URL:
Arafat M, Gabr S, Ghaffar IA, Rahman AA, Hamza Z, Fattah AA, Fattah MA, Mira M. The association between serum thyroid-stimulating hormone concentration and development of differentiated thyroid cancers in nodular thyroid disease. J Arab Soc Med Res [serial online] 2014 [cited 2020 Oct 25 ];9:28-32
Available from: http://www.new.asmr.eg.net/article.asp?issn=1687-4293;year=2014;volume=9;issue=1;spage=28;epage=32;aulast=Arafat;type=0