Year : 2015 | Volume
: 10 | Issue : 1 | Page : 27--31
Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity
Enas R Abd El Hamid1, Azza A Abdel-Shaheed1, Rania N Sabry1, Eman R Youness2, Mones M Abu Shady1, Amr Said Megawer3, Nadia A Mohamed2
1 Department of Child Health, National Research Center, Cairo, Egypt
2 Department of Medical Biochemistry, National Research Center, Cairo, Egypt
3 Department of Pediatrics, Research Institute of Ophthalmology, Cairo, Egypt
Obesity is becoming an epidemic health problem. Elevated cytokines and chemokines are prominent features in obesity, which play a main role in the development of other chronic diseases. The aim of this study was to determine the serum levels of monocyte chemoattractant protein-1 (MCP-1), interlukin-6 (IL-6), and serum paraoxonase-1 (PON1) in childhood obesity.
Materials and methods
The present study included 40 obese school-aged children (5-15 years) and 40 healthy children as controls. The patients were presented to the outpatient clinic in National Institute of Nutrition. MCP-1, IL-6, PON1, total cholesterol, and triglycerides were measured in all participants.
The mean serum levels of MCP-1, IL-6, and total cholesterol were significantly higher in obese participants than in controls (P < 0.0001), whereas the PON1 was significantly lower in obese participants than in controls (P < 0.0001). MCP-1, IL-6, and serum cholesterol levels showed significant positive correlation with BMI (P < 0.05), whereas PON1 showed a significant negative correlation with BMI (P < 0.05). Multiple regression analysis showed a strong association between PON1 activity and BMI (P < 0.0001).
Childhood obesity is associated with increased serum MCP-1 and IL-6 and decreased PON1 and hypercholesterolemia suggesting an increase in adulthood disease risk. Measuring serum MCP-1, IL-6, PON1 activity in obese children may be a good predictor for future chronic disease development and complications.
Rania N Sabry
Department of Child Health, National Research Centre, El Bouhooth Street, 12311 Dokki, Cairo
|How to cite this article:|
Abd El Hamid ER, Abdel-Shaheed AA, Sabry RN, Youness ER, Abu Shady MM, Megawer AS, Mohamed NA. Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity.J Arab Soc Med Res 2015;10:27-31
|How to cite this URL:|
Abd El Hamid ER, Abdel-Shaheed AA, Sabry RN, Youness ER, Abu Shady MM, Megawer AS, Mohamed NA. Serum levels of monocyte chemoattractant protein-1, interlukin-6, and paraoxonase-1 in childhood obesity. J Arab Soc Med Res [serial online] 2015 [cited 2020 Aug 14 ];10:27-31
Available from: http://www.new.asmr.eg.net/article.asp?issn=1687-4293;year=2015;volume=10;issue=1;spage=27;epage=31;aulast=Abd;type=0