Year : 2016 | Volume
: 11 | Issue : 2 | Page : 43--49
Clinicopathological study of pituitary adenomas in the region of northeast india
Mrinal Bhuyan1, Dipti Sarma2, Deep Dutta1, Yogesh Yadav2, Sarat Das3
1 Department of Neurosurgery, Gauhati Medical College, Guwahati, Assam, India
2 Department of Endocrinology, Gauhati Medical College, Guwahati, Assam, India
3 Department of Pathology, Gauhati Medical College, Guwahati, Assam, India
Pituitary adenomas (PA) are the most common tumours of the pituitary gland. Clinicopathological characteristics of these tumours may vary from population to population. The present study aimed to understand the detailed clinical and pathological characteristics of surgically resected PA in the region of Northeast India.
Patients and methods
Thirty-two consecutive cases of PA diagnosed and operated at Gauhati Medical College were studied for clinical, pathological, and treatment characteristics in this study between January 2014 and December 2015. The patient group included 20 female and 12 male patients with a median age of 37 years (range: 22–58 years).
A total of 13/32 (40.63%) cases were nonfunctioning adenomas. Among the hormonally active PA, prolactin-producing adenomas were most common (25%), followed by growth hormone-producing adenomas (18.8%) and adrenocorticotrophic hormone-producing adenomas (15.6%). The most common symptom was headache, followed by visual disturbances, galactorrhoea, acromegaloid and cushingoid features. Menstrual disturbances were present in 50% of the female patients. 23.1% of the cases of nonfunctioning PA were negative for all anterior pituitary hormones on immunohistochemistry.
PA can have varied presentations. Detailed clinical, hormonal and pathological evaluation is essential for better understanding the nature of the tumour growth and its progression. This study is the first of its kind in the region of Northeast India, showing the relationship of the functioning and nonfunctioning PA with their hormonal profile and immunohistochemical analysis.
Department of Neurosurgery, Gauhati Medical College, Guwahati 781032, Assam
|How to cite this article:|
Bhuyan M, Sarma D, Dutta D, Yadav Y, Das S. Clinicopathological study of pituitary adenomas in the region of northeast india.J Arab Soc Med Res 2016;11:43-49
|How to cite this URL:|
Bhuyan M, Sarma D, Dutta D, Yadav Y, Das S. Clinicopathological study of pituitary adenomas in the region of northeast india. J Arab Soc Med Res [serial online] 2016 [cited 2018 May 25 ];11:43-49
Available from: http://www.new.asmr.eg.net/article.asp?issn=1687-4293;year=2016;volume=11;issue=2;spage=43;epage=49;aulast=Bhuyan;type=0