Year : 2017 | Volume
: 12 | Issue : 2 | Page : 39--45
Cardioprotective effects of vitamin B complex and Ethinyl Estradiol in ovariectomized rats
Bassant M.M Ibrahim1, Hanan F Al-Saeed2, Aziza B Shalby3
1 Department of Pharmacology, National Research Centre, Giza, Egypt
2 Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
3 Department of Hormones, National Research Centre, Giza, Egypt
Background/aim Reduction of female sex hormones is associated with health disorders including cardiovascular diseases such as hypertension. Supplementation with vitamin B complex can lower the incidence of these disorders. The present study aimed to study the potential cardioprotective effects of vitamin B complex and ethinyl estradiol (EE) when administered alone or in combination to hormonal-deprived ovariectomized (OVX) rats.
Materials and methods Fifty female Wister rats were classified into five equal groups: the first group included normal rats, the second group was OVX (positive control), and the third to fifth groups were OVX rats that were treated by EE (0.03 mg/kg), vitamin B complex (9.036 mg/kg), and a combination of both treatments, respectively. Treatment continued for eight successive weeks. Blood pressure (BP), cystathionine γ-lyase (CSE), reduced glutathione (R-GSH), superoxide dismutase (SOD), catalase (CAT), and interleukin-β6 (IL-β6) were measured.
Results The OVX rats showed a significant increase in BP, reduction in CSE, R-GSH, SOD, and CAT, and increase in IL-β6 levels, whereas the treated OVX rats showed a significant decrease in BP, increase in CSE, R-GSH, SOD, and CAT, and reduction in IL-β6 levels.
Conclusion Vitamin B complex and EE exert cardioprotective effects in OVX rats.
Bassant M.M Ibrahim
Department of Pharmacology, National Research Centre, El-Bohouth Street (former El-Tahrir Street), Dokki, PO Box 12622, Giza
|How to cite this article:|
Ibrahim BM, Al-Saeed HF, Shalby AB. Cardioprotective effects of vitamin B complex and Ethinyl Estradiol in ovariectomized rats.J Arab Soc Med Res 2017;12:39-45
|How to cite this URL:|
Ibrahim BM, Al-Saeed HF, Shalby AB. Cardioprotective effects of vitamin B complex and Ethinyl Estradiol in ovariectomized rats. J Arab Soc Med Res [serial online] 2017 [cited 2020 Jan 22 ];12:39-45
Available from: http://www.new.asmr.eg.net/article.asp?issn=1687-4293;year=2017;volume=12;issue=2;spage=39;epage=45;aulast=Ibrahim;type=0