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  Indian J Med Microbiol
 

Figure 1 Micrograph of liver sections stained with hematoxylin and eosin (H&E): (a) the control group showing normal hepatic cells with well-preserved cytoplasm, central veins (CV), prominent nucleus (N) and visible sinusoids (S), (b) thioacetamide (TAA) group showing distortion of the hepatic architecture, extensive intralobular fibrosis of both porto-portal and porto-central bridging fibrosis with collagen septa formation, massive number of inflammatory cells infiltration (arrow), necrotic hepatocytes (arrowhead) with severe ballooning degeneration (star), (c) P. granatum peels extract (200 mg/kg) showing normal hepatic architecture and preserved lobular pattern with the CV and rounded nuclei (N), (d) TAA and silymarin showing maintained hepatic architecture with minimal damage, mild necrosis around central vein (arrowhead), mild vacuolar degeneration of hepatocytes (arrowhead). and thin collagenous septa formation with inflammation (arrow), (e) TAA and P. granatum peels extract (100 mg/kg) showing partially preserved hepatocytes, moderate necrosis around the central vein (arrowhead), mild vacuolar degeneration of hepatocytes (H), activation of Kuppfer cell (K) and the collagen fibers were thinner than those noticed in the TAA group (arrow), and (f) TAA and P. granatum peels extract (200 mg/kg) showing minimal damage in the hepatic lobule. The necrotic areas of hepatocytes were replaced by normal cells with thin collagenous septa formation (arrow) (H&E, ×400).

Figure 1 Micrograph of liver sections stained with hematoxylin and eosin (H&E): (a) the control group showing normal hepatic cells with well-preserved cytoplasm, central veins (CV), prominent nucleus (N) and visible sinusoids (S), (b) thioacetamide (TAA) group showing distortion of the hepatic architecture, extensive intralobular fibrosis of both porto-portal and porto-central bridging fibrosis with collagen septa formation, massive number of inflammatory cells infiltration (arrow), necrotic hepatocytes (arrowhead) with severe ballooning degeneration (star), (c) <i>P. granatum</i> peels extract (200 mg/kg) showing normal hepatic architecture and preserved lobular pattern with the CV and rounded nuclei (N), (d) TAA and silymarin showing maintained hepatic architecture with minimal damage, mild necrosis around central vein (arrowhead), mild vacuolar degeneration of hepatocytes (arrowhead). and thin collagenous septa formation with inflammation (arrow), (e) TAA and <i>P. granatum</i> peels extract (100 mg/kg) showing partially preserved hepatocytes, moderate necrosis around the central vein (arrowhead), mild vacuolar degeneration of hepatocytes (H), activation of Kuppfer cell (K) and the collagen fibers were thinner than those noticed in the TAA group (arrow), and (f) TAA and <i>P. granatum</i> peels extract (200 mg/kg) showing minimal damage in the hepatic lobule. The necrotic areas of hepatocytes were replaced by normal cells with thin collagenous septa formation (arrow) (H&E, ×400).