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  Indian J Med Microbiol
 

Figure 2 (a) A case of oral squamous cell carcinoma clinically presenting in the form of speckled leukoplakia; (b) visually enhanced lesion scope examination showing loss of fluorescence, that is, positive result; (c) toluidine blue staining of the lesion showing retention of the stain, that is, positive result; (d) hematoxylin and eosin stained section of the same case showing hyperplastic and hyperkeratotic stratified squamous epithelium with signs of malignancy and rupture of basement membrane detected in some areas. Epithelial masses showed hyperchromatism and abnormal mitotic figures. The underlying connective tissue shows intense inflammatory cell infiltrate.

Figure 2 (a) A case of oral squamous cell carcinoma clinically presenting in the form of speckled leukoplakia; (b) visually enhanced lesion scope examination showing loss of fluorescence, that is, positive result; (c) toluidine blue staining of the lesion showing retention of the stain, that is, positive result; (d) hematoxylin and eosin stained section of the same case showing hyperplastic and hyperkeratotic stratified squamous epithelium with signs of malignancy and rupture of basement membrane detected in some areas. Epithelial masses showed hyperchromatism and abnormal mitotic figures. The underlying connective tissue shows intense inflammatory cell infiltrate.