Figure 5 A photomicrograph of brain tissue sections stained immunohistochemically with GFAP antibody. (a) Normal GFAP activity. (b) Rats treated with toluene show marked decrease of GFAP activity. The astrocytes appear with smaller cell body and shorter processes when compared with normal cells in (a). (c) Rats treated with toluene and 150 mg citicoline show slight increase in GFAP activity. (d) Rats treated with toluene and 300 mg citicoline show marked increase in GFAP activity and in cell body size (GFAP, ×400). GFAP, glial fibrillary acidic protein.