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  Indian J Med Microbiol
 

Figure 2 Proximal metaphysic of tibia of the GIO rats using H&E (a, b, c, and d) and toluidine blue (e and f). (a) Marked thinning of cortical bone (×100), (b) loss of the normal architecture of trabeculae of cancellous bone (×200), (c) discontinuous thinned bony ossicles separated by widened bone marrow (BM) (×200), and (d) poorly calcified bone trabeculae. Toluidine blue-stained sections show (e) cancellous bone trabeculae appeared as discontinuous bony ossicles ‘black arrows’ with widened bone marrow (BM) spaces (×200) and (f) eroded surface of a trabecula with increased number of osteoclasts (OCL) and the erosion cavities detected ‘red arrows’ (×400). GIO, glucocorticoids-induced osteoporosis.

Figure 2 Proximal metaphysic of tibia of the GIO rats using H&E (a, b, c, and d) and toluidine blue (e and f). (a) Marked thinning of cortical bone (×100), (b) loss of the normal architecture of trabeculae of cancellous bone (×200), (c) discontinuous thinned bony ossicles separated by widened bone marrow (BM) (×200), and (d) poorly calcified bone trabeculae. Toluidine blue-stained sections show (e) cancellous bone trabeculae appeared as discontinuous bony ossicles ‘black arrows’ with widened bone marrow (BM) spaces (×200) and (f) eroded surface of a trabecula with increased number of osteoclasts (OCL) and the erosion cavities detected ‘red arrows’ (×400). GIO, glucocorticoids-induced osteoporosis.